Overview
Knowledge discovery in large and complex 'omics data sets remains a key challenge in current life sciences.
A common practice is to apply computational workflows to 'predigest' the big data into lists of significant
features or functions. Although very useful, these 'predigestion' procedures based on meta-data of interest and pior knowledge
can lead to loss of potentially important information. To address this issue, we developed OmicsAnalyst to allow researchers
to work with big omics data in a data-driven and unbiased manner, by integrating three key techniques
- dimensionality reduction, unsupervised clustering, and 3D visual analytics with applications for
single-cell RNAseq and multi-omics data analysis.
Its key features include:
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Supporting various dimensionality reduction algorithms (PCA, MDS, isomap, t-SNE, UMAP and PHATE) for scRNAseq analysis;
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Supporting well-established multivariate methods (Procrustes analysis, multiple co-inertia analysis, and regularized CCA) for multi-omics integration;
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Navigating the data space through clusters analysis and 3D visual analytics;
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Interpreting clusters through exploring impactful features and functional enrichment analysis
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